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講者：謝明發教授
演講題目：3D Priting of Polymeric Biomaterials for Orthopedic Applications
演講時間：11/21（五）15:30~17:00
演講地點：博雅館 103
主持人：吳嘉文教授
3D Printing of Polymeric Biomaterials for Orthopedic Applications
Chih-Hsiang Fang1, Cho-Pei Jiang2, Ming-Fa Hsieh1,*, Hung-Maan Lee3
1Department of Biomedical Engineering, Chung Yuan Christian University, Taiwan
2Institute of Mechanical and Electro-Mechanical Engineering, National Formosa University, Taiwan
3Taoyuan Armed Forces General Hospital, Taiwan
*Email: mfhsieh@cycu.edu.tw
Abstract
Degenerative diseases of bone has gained a great attention because afflicted elderly population is increasing worldwide. The surgery is currently the main intervention to repair the diseased parts such as degenerative disc disease. Likewise, the patient-specific orthopedic devices are considered a better choice to fit into the patients with racial differences around the world. Recently rapid prototyping (or called solid freeform fabrication) has emerged to produce custom-made objects including orthopedic implants. Therefore, this study employed a home-made air pressure-assisted nozzle system to fabricate porous scaffolds of poly (ethylene glycol)-block-(e-caprolacton) designed by a three-dimensional drawing of the computer aided design drawing. The nozzle system features a quick translation of 3D drawing to ready-to-implantation scaffolds. Additionally, to facilitate the adhesion and spreading of osteoblast cells, oligopeptide RGD was introduced to the surface of the scaffold by reacting RGD peptide with PEG-PCL copolymer functionalized with the terminal group of carboxylic acid. The scanning electron microscopic images of RGD-modified scaffolds cultured with osteoblast cells showed profound attachment and spreading of the cell as cultured time increased. Yet the compressive strength of hydroxyapatite-doped scaffolds was enhanced. The implantation of multi-layered scaffolds from the cartilage surface into subcondrol bone in the tibia of New Zeeland rabbits displayed full healing of subcondral bone while the cartilage was partly filled with fibrous tissue. To induce biphasic tissue formation (osteochondral tissues) we have investigated hyaluronic acid hydrogel to the site of injury.
Keywords: Osteoarthritis、Rapid prototyping、cartilage repair、scaffold
關於本次演講資訊請參考附件檔案，謝謝。
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