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講者：Prof. Annalisa Tirella
演講題目：How to play an active role and interact with biological microsystems?
字數統計：0 發表 預覽 狀態： 草稿 編輯 編輯狀態 可見度： 公開的 編輯 編輯可見度 立刻發表 年
演講時間：2/21(五)10：20AM
演講地點：化工館工223室
主持人：王勝仕教授
How to play an active role and interact with biological microsystems?
Annalisa Tirella
Institute of Clinical Physiology, National Research Council, Pisa, Italy
New applications for hydrogels have emerged in biotechnology and biomedical applications, but most notably in stem cell and cancer research, cell therapy, tissue engineering, and in vitro models. These applications require more than the typical triad of stimuli (i.e. mechano-structural, physic-chemical and biochemical features) in a controlled microenvironment. Indeed, in the context of investigating and then recapitulating the complexity of biological systems, there is a need to modulate and control microenvironments designed on biomimicry of the extracellular matrix (ECM). Typically hydrogels have been tuned and used to fabricate such microenvironments. Shaped as useful three-dimensional (3D) systems, they were recently used as exploratory tools to study the presentation of specific bioactive factors on cell fate. Using different methodologies and/or fabrication tools, hydrogels micro-constructs can be assembled in well-defined structural materials and surfaces that display sophisticated functions in order to recreate a microenvironment with tailored properties. In this perspective the nano-in-micro concept foresees the inclusion if nano-tools (e.g. nanosensors, photo-sensitive biomolecules, drugs) in such gel systems. Nano-in-micro spherical hydrogels can be easily designed and fabricated using different rapid prototyping strategies. By entrapping several kinds of sensing, living and active domains, nano-in-micro systems can be assembled to biomimic a target physiological and living microenvironment. Thus, even being a Gulliver in a system ruled by Lilliputians, this approach will enable the interrogation of biological in vitro systems helping to understand the fate of many pathophysiological states.
關於本次演講資訊請參考附件檔案，謝謝。
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