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講者：Prof. Klavs F. Jensen
演講題目：Chemical and Biological Microsystems – Advantages of going small
演講時間：1/13（一）下午4：00
演講地點：化工館化工一教室
主持人：王大銘教授
Klavs F. Jensen Bio:
Klavs F. Jensen is Warren K. Lewis Professor and Head of the Chemical Department at the Massachusetts Institute of Technology. He received his chemical engineering education from the Technical University of Denmark (M.Sc.) and University of Wisconsin-Madison (PhD). His research interests include microsystems for chemical and biological discovery, synthesis and processing. Catalysis, chemical kinetics and transport phenomena are also topics of interest along with development of simulation approaches for reactive chemical and biological systems. He is the co-author of more than 330 journal articles as well as several edited volumes and 30 US patents. He serves on advisory boards to universities, companies, professional societies, and governments. He is the recipient of numerous awards, including the Allan P. Colburn, Charles C.M. Stine, R.H. Wilhelm, and W.H. Walker Awards of the American Institute of Chemical Engineers. Professor Jensen is a member of the US National Academy of Engineering and the American Academy of Arts and Science. He is also a Fellow of the American Association for the Advancement of Science (AAAS), and the American Institute of Chemical Engineers, and the Royal Society of Chemistry.
Abstract:
Microfabrication techniques have fueled spectacular advances in the electronic and telecommunications industries, and more recently, in microanalysis chips for chemical and biological applications. These systems promise to transform classical laboratory procedures into integrated systems capable of providing new understanding of fundamental chemical and biological processes as well as rapid, continuous discovery and development of new products with less use of resources and waste generation. Chemical microsystems combine chemical-synthesis-on-a chip and microscale separation to enable multiple synthesis steps, which are further enhanced by information gained from integrating miniaturized sensors and actuators. Biological studies are similarly accelerated by the integration of cell manipulation and biochemical detection. Applications of chemical and biological microsystems are illustrated with case studies drawn from chemical transformations, synthesis and assembly of nano structures, and cellular manipulation. Emphasis is placed on applications that are enabled by flow systems and are difficult to perform by conventional techniques. Flow chemistry examples include the creation of modular chemical plants for small scale pharmaceutical production. Cellular manipulation is illustrated with microfluidic devices for delivery of macromolecules and nanoparticles to the cytosol. This technique has superior ability to deliver proteins, siRNA, and nanoparticles, while maintaining material functionality and cell viability.
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