講者：胡哲銘助研究員 演講題目：Nanoparticle Biointerfacing by Cell Membrane Cloaking for Biomedical Applications 演講時間：3/31（五）15:30~17:20 演講地點：博雅館 201 主持人：蔡偉博教授
Nanoparticle Biointerfacing by Cell Membrane Cloaking for Biomedical Applications
Che-Ming Jack Hu, PhD
Institute of Biomedical Sciences, Academia Sinica
128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan
chu@ibms.sinica.edu.tw
Cell membranes present a unique interface that governs numerous biological events in physiology as well as in disease pathogenesis; exploiting this interface for therapeutic development promises novel treatment modalities with biomimetic functionalities. Reported herein is a nanoparticle functionalization strategy that cloaks particles with natural cellular membranes, which can be derived from different cellular targets. Optimization of nanoparticle surface chemistry has enabled cell membranes to conform over nanoparticles in a unilamellar and right-side-out manner, effectively functionalizing the particles with membrane lipids, associated membrane proteins, and surface glycans. The technique has been applied to cellular membranes derived from red blood cells, platelets, and cancer cells, and the resulting nanoparticles have been shown to adopt numerous cell-like functionalities, including biomimetic interactions with the immune system, toxins, pathogens, and endothelium. Several therapeutic applications, such as long-circulating drug delivery, targeted drug delivery, biodetoxification, and vaccine preparation, were demonstrated with the cell membrane cloaked nanoparticles in animal models. The biomimetic nanoparticles have significant therapeutic potentials in treating cancer, cardiovascular disease, autoimmune disease, and infection. The work also highlights the intricate interfacial dynamics at the nanoscale, which has immense implications in the design and characterizations of nanoparticles. References
- C.-M. Hu, L. Zhang, S. Aryal, C. Cheung, R. Fang, L. Zhang, Proceedings of the National Academy of Sciences, 108, 10980, (2011).
- C.-M. Hu, R. Fang, J. Copp, B. Luk, L. Zhang, Nature Nanotechnology, 8, 336, (2013).
- C.-M. Hu, R. Fang, B. Luk, L. Zhang, Nature Nanotechnology, 8, 933, (2013).
- C.-M. Hu, R. Fang, K.-C. Wang, B. Luk, S. Thamphiwatana, D. Dehaini, P. Nguyen, P. Angsantikul, C.H. Wen, A. Kroll, C. Carpenter, M. Ramesh, V. Qu, S. Patel, J. Zhu, W. Shi, F. M. Hofman, T. C. Chen, W. Gao, K. Zhang, S. Chien, L. Zhang, Nature, 526, 118, (2015).
關於本次講者資訊請參考附件檔案，謝謝。