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王勝仕 教授 / Steven S.-S. Wang Professor

生物分子工程研究室 Biomolecular Engineering Lab 一館 神經科學蛋白質工程細胞工程生化工程奈米科技在生物分子工程上之應用生物分子模擬 Neuroscience, Protein engineering, Cellular engineering, Biochemical engineering, Nanotechnology in biomolecular engineering, Biomolecular dynamics simulations (02)3366-5870 BLDG. I (02)3366-3057 sswang@ntu.edu.tw 308 王勝仕 Steven Sheng-Shih Wang 化工一館 CheE BLDG. I 教授 Professor 117
    • 學經歷
      • 中央大學     化學工程學士,1991
      • 台灣大學     化學工程學士,1993
      • 美國德州農工大學 化學工程博士,2002

     

    • 研究主題
      • 研究神經疾病之發生機制
        嘗試以不同之工程與生化方法或工具探討及瞭解與蛋白質聚集形成相關等疾病(例如:阿滋海默症,巴金斯症,狂牛病等類澱粉症,青光眼,及白內障等)之主要發生機制,並進而尋求有效之抑制分子與預防方法。研究相關應用之領域包括:細胞工程、細胞生物學、蛋白質工程、神經科學。
      • 奈米技術或材料在生物領域上之應用
        著重於利用生物分子之特殊性質來合成具奈米等級之材料;或發展生物分子及奈米材料之偵測系統。

     

    • 最新研究
      • Effect of Reduction-Oxidation Composition on the Fibrillogenesis of Amyloid Proteins. 氧化還原組成對於蛋白質類澱粉形成之影響 Sheng-Shih Wang, sponsored by National Science Council, NSC98-2221-E-002-063-MY3, 8/01/2009-7/31/2010.
    1. 2015生物技術暨生化工程國際研討會, Organizing Committee
    2. 指導楊斯閔、陳宜琳、陳郁涵、戴承葦、張牧月同學與博士研究生侯素君同學獲2015生物技術暨生化工程國際研討會 ”Best Oral Presentation Award”
    3. 指導碩士研究生陳仁偉與張智凱同學獲2015生物技術暨生化工程國際研討會 ”Outstanding Oral Presentation Award”
    4. YABEC (Symposium of Young Asian Biochemical Engineers' Community), Taiwan regional delegate (台灣區負責人), 2015-2018
    5. Asian Federation of Biotechnology (AFOB), Executive Board Committee Member, 2015 – 2018.
    6. Asian Federation of Biotechnology (AFOB), Advisory Board Member, 2019 – now
    7. 2015化工年會生化與生醫工程組 Invited Speaker
    8. 指導鍾旻芝(研究生)、曾佳平(大學部專題生)、郭俊廷(大學部專題生)、許皦侖(大學部專題生)、鄭瑀鴻(研究學者),參加"2016生物技術暨生化工程國際研討會",獲得英文口頭論文發表競賽優勝
    9. 2016化工年會生化與生醫工程組學術委員會委員
    10. 2016化工年會生化與生醫工程組, Session Chair
    11. 指導博士研究生侯素君參加 "2016化工年會"獲得海報論文發表競賽佳作
    12. 2017 BEST Conference and International Symposium on Biotechnology and Bioengineering, Organizing Advisory Committee
    13. 指導徐瑋澤同學參加 "2017生物技術暨生化工程國際研討會"獲得英文口頭論文發表競賽優勝
    14. 擔任2017化工年會生化與生醫工程組學術委員會委員 (Academic Committe)
    15. 指導徐瑋澤同學參加"2017化工年會"獲得英文口頭論文發表競賽優勝
    16. 指導徐瑋澤同學參加2017明志科技大學綠色生物程序工程論壇與生化工程技術研發中心成果發表會獲得3 Minute Thesis Competition英文口頭論文發表競賽第二名及海報論文發表競賽第一名
    17. ”Biotechnology and Bioprocess Engineering” Journal, Editorial Advisory Board Member. 2018-2020.
    18. 2018 BEST Conference and International Symposium on Biotechnology and Bioengineering, Advisory Committee
    19. 2018 BEST Conference and International Symposium on Biotechnology and Bioengineering, Session Chair of Keynote Speech IV
    20. 主辦第24屆亞太青年生化工程國際研討會 (The 24th Symposium of Young Asian Biological Engineers’ Community (YABEC 2018)), 擔任大會主席 (Chairman)
    21. 指導楊斯閔同學獲第24屆亞太青年生化工程國際研討會(YABEC 2018)大會”YABEC 2018 The Best Poster Award”獎項
    22. 擔任第十四屆亞洲生物技術大會 (The 14th Asian Congress on Biotechnology, ACB 2019), Scientific Committee Member
    23. 榮獲亞洲生物技術聯盟 (Asian Federation of Biotechnology) (2019年) 年度傑出貢獻獎 (Excellent Service Award)
    24. “Biotechnology and Bioprocess Engineering” Journal, Editorial Advisory Board Member, 2018.1- 2019.12
    25. 擔任2020 TwIChE 台灣化學工程學會67週年年會” 生化及生醫工程組” Invited speaker
    26. 擔任2021 TwIChE 台灣化學工程學會68週年年會”學術論壇—生化及生醫工程組” Session Chair
    27. 指導大四盧欣同學榮獲12th Green Sustainable Biotechnology Symposium (2022綠色永續生物科技研討會) 3MT (3 Min) 英文口頭論文發表競賽優勝 (First place)
    28. 指導博士生賴宥任同學參加 "2022 BEST Conference & International Symposium on Biotecnology and Bioengineering"獲得 Best Oral Presentation Award
    29. 指導博士生賴宥任同學參加 "The 69th Annual Meeting of the Taiwan Institute of Chemical Engineers "獲得 Best Oral Presentation Award
    30. 指導碩士生涂家齡同學參加 "The 69th Annual Meeting of the Taiwan Institute of Chemical Engineers "獲得 Honorable Mention Award
    31. 台灣生物技術與生化工程學會(BEST), 國際事務委員會委員, 2019 – 2022
    32. 台灣生物技術與生化工程學會(BEST), 常務理事, 2019 – 2022
    33. 台灣生物技術與生化工程學會(BEST), 理事, 2022 – now
    34. 2023 BEST (Biotechnology and Biochemical Engineering Society of Taiwan) joint YABEC (Young Asian Biological Engineers’ Community), Organizing Committee.
    35. 2023 BEST (Biotechnology and Biochemical Engineering Society of Taiwan) joint YABEC (Young Asian Biological Engineers’ Community), Scientific Committee.
    36.  “International Journal of Biological Macromolecule (IF = 8.025)” Journal Editor, 2020.3-now
  • 1.  N. V. Mdlovu, Y. Chen, K. S. Lin, M. W. Hsu, S. S.-S. Wang*, C. M. Wu, Y. S. Lin and K. Ohishi, “Multifunctional nanocarrier as a potential micro-RNA delivery vehicle for neuroblastoma treatment”, J Taiwan Inst Chem E 96, 526-537, (2019) (SCI)
    2.  N. V. Mdlovu, F. A. Mavuso, K. S. Lin, T. W. Chang, Y. Chen, S. S.-S. Wang, C. M. Wu, N. B. Mdlovu and Y. S. Lin, “Iron oxide-pluronic F127 polymer nanocomposites as carriers for a doxorubicin drug delivery system”, Colloid Surface A 562, 361-369, (2019) (SCI)
    3.  C. Y. Lin,T. H. Wang, S. C. How, Z. Bednarikova, D. Fedunova, Z. Gazova, J. W. Wu, and S. S.-S. Wang*, “Investigating the effect of sugar-terminated nanoparticles on amyloid fibrillogenesis of β-lactoglobulin”, Int J Biol Macromol, 165, 291–307 (2020) (SCI)
    4.  J. H. Liou, Z. H. Wang, I. H Chen, S. S.-S. Wang, S. C. How, and J. S. Jan, “Catalase immobilized in polypeptide/silica nanocomposites via emulsion and biomineralization with improved activities”, Int J Biol Macromol, 159, 931–940 (2020) (SCI).
    5.  Y. C. Wang, Y. R. Lai, J. W. Wu, S. S.-S. Wang*, K. S. Lin, “Using palladium nanoparticle-decorated lysozyme amyloid fibrils to catalyze the reduction of methylene blue”, J Taiwan Inst Chem E, 118, 187-195 (2021) (SCI).
    6.  M. J. C. Espinoza, K. S. Lin, M. T. Weng, S. C. Kunene, S. S.-S. Wang*, ” In vitro studies of Pluronic F127 coated magnetic silica nanocarriers for drug delivery system targeting liver cancer”, European Polymer Journal 153, 110504 (2021) (SCI).
    7.  S. S. Hsueh, J. H. Lu, J. W. Wu, T. H. Lin, S. S.-S. Wang*, “Protection of human D-crystallin protein from ultraviolet C-induced aggregation by ortho-vanillin”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 261, 120023 (2021) (SCI).
    8.  S. C. How, T. H. Lin, C. C. Chang, S. S.-S. Wang*, “Examining the effect of bovine serum albumin on the properties and drug release behavior of β-lactoglobulin-derived amyloid fibril-based hydrogels”, Int J Biol Macromol, 184, 79–91 (2021) (SCI).
    9.  A. Hsin, S. C. How, S. S.-S. Wang*, C. W. Ooi, C. Y. Chiu, Y. K. Chang, “Kinetic and Thermodynamic Studies of Lysozyme Adsorption on Cibacron Blue F3GA Dye-Ligand Immobilized on Aminated Nanofiber Membrane”, Membranes, 11, 963 (2021) (SCI).
    10.  Y. S. Chen, C. W. Ooi, P. L. Show, B. C. Hoe, W. S. Chai, C. Y. Chiu, S. S.-S. Wang*, Y. K. Chang, “Removal of Ionic Dyes by Nanofiber Membrane Functionalized with Chitosan and Egg White Proteins: Membrane Preparation and Adsorption Efficiency”, Membranes 12, 63 (2022) (SCI).
    11.  S. S. Hsueh, S. S.-S. Wang, S. H. Chen, C. L. Wang, J. W. Wu, T. H. Lin, “Insights to Human γD-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations”, International Journal of Molecular Sciences 23, 1591 (2022) (SCI). 
    12.  R. Z. Huang, K. H. Chen, C. W. Ooi, B. C. Hoe, Y. R. Lai, M. Hsu, C. Y. Chiu, S. S.-S. Wang*, Y. K. Chang, “Direct recovery of malate dehydrogenase from highly viscous yeast cell homogenate by a fluidized bed contactor equipped with an agitator”, Biochemical Engineering Journal 183, 108461 (2022) (SCI).
    13.  Y. R. Lai, J. T. Lai, S. S.-S. Wang*, Y. C. Kuo, T. H. Lin, “Silver nanoparticle-deposited whey protein isolate amyloid fibrils as catalysts for the reduction of methylene blue”, Int J Biol Macromol, 213, 1098–1114 (2022) (SCI).
    14.  Y. R. Lai, T. H. Wang, S. C. How, K. S. Lin, W. L. Chou, S. S.-S. Wang*, “Using Sugar-Derived Nanoparticles to Mitigate Amyloid Fibril Formation of Lysozyme”, J Taiwan Inst Chem E, 137, 104360 (2022) (SCI).
    15.  S. J. Jian, S. S.‑S. Wang, C. W. Ooi. B. C. Hoe, Y. R. Lai, C. Y. Chiu, M. Hsu, K. H. Chen, Y. K. Chang, “ Cellulose-based nanofiber membrane functionalized with dye affinity ligand for purification of malate dehydrogenase from Saccharomyces cerevisiae”, Cellulose, 29, 9251–9281 (2022) (SCI).
    16.  J. L. Hsu, S. S.-S. Wang, C. W. Ooi, X. E. C. Thew, Y. R. Lai, C. Y. Chiu, M. Hsu, K. H. Chen, Y. K. Chang, “Reactive Green 19 dye-ligand immobilized on the aminated nanofiber membranes for efficient adsorption of lysozyme: Process development and optimization in batch and flow systems”, Food Chemistry, 406, 135028 (2023) (SCI).
    17.  S. S. Dwitya, Y. H. Hsueh, S. S.-S. Wang*, K. S. Lin, “Ultrafine nitrogen-doped graphene quantum dot structure and antibacterial activities against Bacillus subtilis 3610”, Materials Chemistry and Physics, 295, 127135 (2023) (SCI).
    18.  S. S. Lu, Y. R. Lai, L. H. Hsiao, H. Y. Huang, Y. H. Tsai, Y. Chen, S. S.-S. Wang *, Y. C. Yeh, S. L. Tsai, “Effects of amino acid-functionalized silver nanoparticles on lysozyme amyloid fibrillogenesis”, Colloids and Surfaces B: Biointerfaces, 222, 113144 (2023) (SCI).
    19.  W. T. Lin, S. C. How, W. Z. Lin, F. H. Chen, W. C. Liao, I. C. Ma, S. S.-S. Wang*, S. Y. Hou, “Using flow cytometry to develop a competitive assay for the detection of biotin”, J Taiwan Inst Chem E, 143, 104691 (2023) (SCI).
    20.  Y. R. Lai, S. S.-S. Wang, T. L. Hsu, S. H. Chou, S. C. How, T. H. Lin, “Application of Amyloid-Based Hybrid Membranes in Drug Delivery”, Polymers, 15, 1444 (2023) (SCI).