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蔡偉博 教授 / Wei-Bor Tsai Professor

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蔡偉博 教授 / Wei-Bor Tsai Professor

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生醫材料實驗室 Biomaterials Laboratory 二館 生物材料組織工程天然高分子材料應用 Surface modification of biomaterials for improvement in biocompatibilityCell responses to surface topographiesBiomaterial development for tissue engineering applications (02)3366-3996 BLDG.II (02)3366-3042 WeiborTsai@ntu.edu.tw N401 蔡偉博 Wei-Bor Tsai 化工二館(鄭江樓) CheE BLDG.II 教授 Professor N406

  • 簡介

    • 學經歷
      • 台灣大學    化工學士  ，1983
      • 台灣大學    生化碩士  ，1991
      • 美國華盛頓大學 生物工程博士，1999

     

    • 研究主題
      • 生醫材料表面改質以增進生物相容性：
        開發新式的表面修飾技術，以提高生醫材料的生物相容性，聚焦於增進材料表面的細胞親和性或抗垢性。
      • 細胞對於材料表面地形的反應：
        研究材料表面的微/奈米地形，對於細胞形態、貼附、生長與分化的影響，以調控細胞行為及應用於組織工程。
      • 開發用於組織工程的生醫材料：
        開發添加生物活性分子，以水膠或奈米電紡絲的形式為主的支架，促進細胞生長及分化。

     

    • 最新研究
      • 紡織產業卓越創新研究中心業務推展 NT$ 400,000, 紡織研究所, 04/01/2009-12/31/2009
      • 製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2009-07/31/2010

  • 代表著作

    1. R. Chang and W. B. Tsai, “Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy”, Polymers-Basel 10, (2018)
    2. C. W. Lin, K. C. Yang, N. C. Cheng, W. B. Tsai, K. L. Lou and J. S. Yu, “Evaluation of adhesion, proliferation, and differentiation of human adipose-derived stem cells on keratin”, J Polym Res 25, (2018)
    3. W. H. Lin, C. Y. Lin, C. C. Tsai, J. S. Yu and W. B. Tsai, “Spheroid Formation of Human Adipose-Derived Stem Cells on Environmentally Friendly BMA/SBMA/HEMA Copolymer-Coated Anti-Adhesive Surface”, B Chem Soc Jpn 91, 1457-1464, (2018)
    4. M. Lu, Y. Liu, Y. C. Huang, C. J. Huang and W. B. Tsai, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive”, Carbohyd Polym 181, 668-674, (2018)
    5. S. K. Rajendrakumar, N. C. Chang, A. Mohapatra, S. Uthaman, B. I. Lee, W. B. Tsai and I. K. Park, “A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model”, Int J Mol Sci 19, (2018)
    6. Y. J. Yang, X. L. Wang, T. C. Huang, X. H. Hu, N. Kawazoe, W. B. Tsai, Y. N. Yang and G. P. Chen, “Regulation of mesenchymal stem cell functions by micro-nano hybrid patterned surfaces”, J Mater Chem B 6, 5424-5434, (2018)
    7. I. N. Ahmed, R. Chang, M. C. Keng, H. W. Chien, H. Y. Chen and W. B. Tsai, “Immobilization of functional polymers on poly(4-benzoyl-pxylylene-co-p-xylylene) films via photochemical conjugation for modulation of cell adhesion”, Colloid Surface B 174, 360-366, (2019)
    8. W. H. Chen, T. Y. Liao, H. Thissen and W. B. Tsai, “One-Step Aminomalononitrile-Based Coatings Containing Zwitterionic Copolymers for the Reduction of Biofouling and the Foreign Body Response”, Acs Biomater Sci Eng 5, 6454-6462, (2019)
    9. Q. H. Cui, T. H. Le, Y. J. Lin, Y. B. Miao, I. T. Sung, W. B. Tsai, H. Y. Chan, Z. H. Lin and H. W. Sung, “A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release”, Nano Energy 66, (2019)
    10. Y. Liu, S. C. Ng, J. S. Yu and W. B. Tsai, “Modification and crosslinking of gelatin-based biomaterials as tissue adhesives”, Colloid Surface B 174, 316-323, (2019)
    11. P. T. Wu, C. L. Lin, C. W. Lin, N. C. Chang, W. B. Tsai and J. S. Yu, “Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells”, Nanomaterials-Basel 9, (2019)
    12. Yeh, Shang-Lin; Deval, Piyush; Wu, Jhih-Guang; Luo, Shyh-Chyang; Tsai, Wei-Bor, One-step electrochemical deposition of antifouling polymers with pyrogallol for biosensing applications, Journal Of Materials Chemistry B, 2021
    13. Yeh, Shang-Lin; Wang, Ting-Ching; Yusa, Shin-ichi; Thissen, Helmut; Tsai, Wei-Bor, Conjugation of Polysulfobetaine via Poly(pyrogallol) Coatings for Improving the Antifouling Efficacy of Biomaterials, Acs Omega, 5(3517),3524-9, Feb 2021.
    14. Wang, Ting-Ching; Tsai, Wei-Bor, A biphasic mathematical model for the release of polymer-drug conjugates from poly(vinyl alcohol) hydrogels, Journal Of The Taiwan Institute Of Chemical Engineers, 135, 2022 FEB.
    15. Deval, Piyush; Lin, Chia-Hsuan; Tsai, Wei-Bor, Fabrication of Polysulfobetaine Gradient Coating via Oxidation Polymerization of Pyrogallol To Modulate Biointerfaces, Acs Omega, 7(8),7125-7133, 2022 SEP.
    16. Chien, Hsiu-Wen; Wu, Jen-Chia; Chang, Ying-Chih; Tsai, Wei-Bor, Polycarboxybetaine-Based Hydrogels for the Capture and Release of Circulating Tumor Cells, Gels, 8(7), 2022 DEC
    17. Sun, Yi-Chen; Wu, Li-Li; Chang, Yu-An; Li, Tzu-Yun; Lin, Yang; Hu, Fung-Rong; Tsai, Wei-Bor; Hung, Kai-Feng, Zwitterionic poly(carboxybetaine methacrylate) (polyCBMA) decreases desiccating damage to corneal epithelial cells, Colloid And Interface Science Communications, 50, 2022 MAR.
    18. Ilona Uzieliene, Daiva Bironaite, Jolita Pachaleva, Edvardas Bagdonas, Arkadij Sobolev, Wei-Bor Tsai, Giedrius Kvedaras, Eiva Bernotiene. Chondroitin Sulfate-Tyramine-Based Hydrogels for Cartilage Tissue Repair. Int J Mol Sci. 2023. 24(4):3451. doi: 10.3390/ijms24043451.
    19. Ilona Uzieliene, Daiva Bironaite, Edvardas Bagdonas, Jolita Pachaleva, Arkadij Sobolev, Wei-Bor Tsai, Giedrius Kvederas, Eiva Bernotiene. The Effects of Mechanical Load on Chondrogenic Responses of Bone Marrow Mesenchymal Stem Cells and Chondrocytes Encapsulated in Chondroitin Sulfate-Based Hydrogel. Int J Mol Sci. 2023. 24(3):2915. doi: 10.3390/ijms24032915.
    20. Tsai WB, Ahmed IN. The Impact of Polyethylene Glycol-Modified Chitosan Scaffolds on the Proliferation and Differentiation of Osteoblasts. Int J Biomater. 2023:4864492. doi: 10.1155/2023/4864492.

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    更新日期

    2024-10-09