講者：崔宏瑋教授
演講題目：Chiral recogntion by enantioselective liquid chromatography
演講時間：4/29（五）15:30~17:20
演講地點：博雅館 201
主持人：陳立仁教授
崔宏瑋 (Hung-Wei Tsui),
Assistant Professor of Chemical Engineering and Biotechnology,
National Taipei University of Technology
Joined NTUT in 2015
B.S., National Taiwan University, 2005
M.S., National Taiwan University, 2007
Ph.D., Purdue University, 2013
Post-Doctoral, National Taiwan University, 2014
Research Interests
Chiral Separation, Chromatography, Molecular Simulations, Molecular Spectroscopy, Colloid Science
Selected Publications
Hung-Wei Tsui, Elias I. Franses, Nien-Hwa Linda Wang, Effect of alcohol aggregation on the retention factors of chiral solutes with an amylose-based sorbent: Modeling and implications for the adsorption mechanism, Journal of Chromatography A, 1328, 52-65, 2014/02
Hung-Wei Tsui, Nien-Hwa Linda Wang, Elias I. Franses, Chiral recognition mechanism of acyloin-containing chiral solutes by amylose tris[(S)-α-methylbenzylcarbamate], The Journal of Physical Chemistry B, 117(31) 9203-9216, 2013/08
Hung-Wei Tsui, Margaret Y. Hwang, Lei Ling, Elias I. Franses, Nien-Hwa Linda Wang, Retention models and interaction mechanisms of acetone and other carbonyl-containing molecules with amylose tris[(S)-α-methylbenzylcarbamate] sorbent, Journal of Chromatography A, 1279, 36-48, 2013/03
Hung-Wei Tsui, Jonathan N. Willing, Rahul B. Kasat, Nien-Hwa Linda Wang, Elias I. Franses, Infrared spectroscopy and molecular simulations of a polymeric sorbent and its enantioselective interactions with benzoin enantiomers, The Journal of Physical Chemistry B, 115, 12785-12800, 2011/09
Abstract
Enantioselective separations of chiral molecules are important in various chemical fields, such as pharmaceuticals and agrochemicals industries. Many drug molecules are chiral molecules. The human body contains numerous chiral sites, which show stereo-specific interactions with only one enantiomer, and may metabolize each enantiomer by separate pathways to produce different pharmacological activities. One enantiomer may be therapeutically effective, while the other may be toxic. Among various chiral separation methods, chromatographic separations are generally used. The recognition mechanisms which determine their enantioselectivities, however, are not completely understood. Many efforts have been made in the past to understand the chiral recognition mechanisms. The present state of the mechanistic studies and real understanding of the underlying mechanisms, however, are far behind their practical applications. The current knowledge in this field does not allow to undoubtedly explain experimental observations, predict chiral separations based on molecular structures, and design more effective materials. The demand of studies in this area is very high. The present talk is attempted as introduction providing an overview about most important modern CSPs and their chiral recognition and separation mechanisms.[:en]Speaker：Prof. Hung-Wei Tsui
Topic：Chiral recogntion by enantioselective liquid chromatography
Date：4/29（五）15:30~17:20
Location：博雅館 201
Host ： Prof. Li-Jen Chen
崔宏瑋 (Hung-Wei Tsui),
Assistant Professor of Chemical Engineering and Biotechnology,
National Taipei University of Technology
Joined NTUT in 2015
B.S., National Taiwan University, 2005
M.S., National Taiwan University, 2007
Ph.D., Purdue University, 2013
Post-Doctoral, National Taiwan University, 2014
Research Interests
Chiral Separation, Chromatography, Molecular Simulations, Molecular Spectroscopy, Colloid Science
Selected Publications
Hung-Wei Tsui, Elias I. Franses, Nien-Hwa Linda Wang, Effect of alcohol aggregation on the retention factors of chiral solutes with an amylose-based sorbent: Modeling and implications for the adsorption mechanism, Journal of Chromatography A, 1328, 52-65, 2014/02
Hung-Wei Tsui, Nien-Hwa Linda Wang, Elias I. Franses, Chiral recognition mechanism of acyloin-containing chiral solutes by amylose tris[(S)-α-methylbenzylcarbamate], The Journal of Physical Chemistry B, 117(31) 9203-9216, 2013/08
Hung-Wei Tsui, Margaret Y. Hwang, Lei Ling, Elias I. Franses, Nien-Hwa Linda Wang, Retention models and interaction mechanisms of acetone and other carbonyl-containing molecules with amylose tris[(S)-α-methylbenzylcarbamate] sorbent, Journal of Chromatography A, 1279, 36-48, 2013/03
Hung-Wei Tsui, Jonathan N. Willing, Rahul B. Kasat, Nien-Hwa Linda Wang, Elias I. Franses, Infrared spectroscopy and molecular simulations of a polymeric sorbent and its enantioselective interactions with benzoin enantiomers, The Journal of Physical Chemistry B, 115, 12785-12800, 2011/09
Abstract
Enantioselective separations of chiral molecules are important in various chemical fields, such as pharmaceuticals and agrochemicals industries. Many drug molecules are chiral molecules. The human body contains numerous chiral sites, which show stereo-specific interactions with only one enantiomer, and may metabolize each enantiomer by separate pathways to produce different pharmacological activities. One enantiomer may be therapeutically effective, while the other may be toxic. Among various chiral separation methods, chromatographic separations are generally used. The recognition mechanisms which determine their enantioselectivities, however, are not completely understood. Many efforts have been made in the past to understand the chiral recognition mechanisms. The present state of the mechanistic studies and real understanding of the underlying mechanisms, however, are far behind their practical applications. The current knowledge in this field does not allow to undoubtedly explain experimental observations, predict chiral separations based on molecular structures, and design more effective materials. The demand of studies in this area is very high. The present talk is attempted as introduction providing an overview about most important modern CSPs and their chiral recognition and separation mechanisms.