講者：楊光教授
演講題目：Controllable Micro/nano Biofabrication of Fascinating Composites based on Bacterial Cellulose
演講時間：3/8(二) 下午3：30
演講地點：化工館化工一教室
主持人：游佳欣教授
楊光教授
學習與工作經歷：
1989年6月，武漢大學化學系獲理學學士學位。
1989年6月-1999年，武漢大學化學系，任助教、講師。
1995年10月-1996年10月，日本旭化成公司高分子研究所合作研究一年。
1999年-2005年，武漢大學化學與分子科學學院，副教授。
2000年6月，武漢大學化學與分子科學學院獲理學博士學位（導師：張俐娜院士）。
2002年4月-2004年4月，德國Mainz大學物理化學研究所，洪堡學者，（合作導師：Prof. B.A. Wolf）。
2004年4月-2006年4月九州大學生物資源環境學院生物材料設計實驗室，日本學術振興會JSPS fellow。 （合作導師：近藤哲男教授）
2006年9月-至今，華中科技大學生命科學與技術學院教授，博士生導師
2010年11月-2011年9月美國Akron大學高分子科學與工程學院高級訪問學者（合作導師：程正迪院士）
研究領域
1.醫用材料
2.藥物載體
3.光電材料
4.有序納米材料組裝
Abstract
Controllable Micro/nano Biofabrication of Fascinating Composites based on Bacterial Cellulose
Guang Yang1,2
1 Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
2 National Engineering Research Center for Nano-Medicine, Huazhong University of Science and Technology, Wuhan 430074, PR China;
Microorganisms in nature have rich variety, whose sizes are from nano to microscale. Therefore, microbes can be used as natural building blocks in nano/micro multilevel fabrication processes. Based on the urgent need of micro/nano biological manufacture of microorganism, four controlling methods: molecular template, magnetic control, microfluidics, and bio-printing for biological manufacture process suitable for microbe have been proposed to dip into the moving mode of microorganism and design new micro/nano functional materials by controlling directed movement and ordered arrangement of microorganism living cells. It could be really creative attempts in the microbial field.
Bacterial cellulose (BC) is secreted by microorganism. Its biocompatibility, mechanical strength, chemical and morphologic controllability make it a natural choice for adoption in biomedical fields, including use as biomaterial for wound dressing, artificial blood vessels, vascular grafts, scaffolds for tissue engineering and controlled-release drug carriers3. More than that, BC is a natural hydrogel, its high water content can carry other monomeric, reactive and potentially polymerizable species into BC’s inner network, essentially occupying the void volume and interacting with chain segments or pendant moieties of the BC. Therefore, Varity of composites based BC were synthesized and expand the application of BC. BC composites are primarily synthesized through in situ addition of reinforcement materials to BC synthetic media or the ex situ penetration of such materials into BC microfibrils. In our group’s research, BC combine with biomacromolecules such as chitosan, hyaluronic acid, collagen, silk fibroin and so on, can be used in wound dressing and cosmetic. BC combine with Poly(NIPAM-co-BMA), which has thermoresponsive property, suitable for vascular embolization interventional therapy. BC combine with carbon nanotubes or conductive polymers, which has electroactive property, can be used as flexible supercapacitor, electrodes, and have potential to be used to build a biology–device interface to produce implantable biosensors, electrostimulated drug release devices, and implantable devices for personalized and regenerative medicine.
References:
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2 Fu L, Zhang Y, Li C, Wu Z, Zhuo Q, Huang X, Qiu G, Zhou P, Yang G.( 2012) Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method. J Mater Chem. 22: 12349-57.
3 Wu L, Zhou H, Sun H, Zhao Y, Yang X, Cheng SZ, Yang G.(2013) Thermoresponsive Bacterial Cellulose Whisker/Poly (NIPAM-co-BMA) Nanogel Complexes: Synthesis, Characterization, and Biological Evaluation. Biomacromolecules. 14: 1078-84.
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