講者：莊怡哲教授
演講題目：Fabrication of flexible and dissolvable polymer microneedle patches via microfiltration
演講時間：10/16（五）15:30~17:20
演講地點：博雅館 201
主持人：謝之真教授
BIOGRAPHY
Dr. Juang received a B.S. degree in chemical engineering from National Taiwan University (Taipei, Taiwan) in 1993 and a Ph.D. degree in chemical engineering from The Ohio State University (Columbus, Ohio, USA) in 2001.
Currently, he is an associate professor of Department of Chemical Engineering at National Cheng Kung University in Taiwan. Before joining National Cheng Kung University in 2005, he worked as a process engineer at ACLARA BioSciences Company (California, USA), a product development manager at Bioprocessing Innovative Company (Ohio, USA) and a postdoctoral researcher at The Ohio State University (Ohio, USA). His research interest includes micro/nanofabrication, micro/nanofluidics, BioMEMS, and polymer microfabrication.
Dr. Juang is a member of “Society of Plastics Engineers-Taiwan Section” and “Nanotechnology and Micro System Association”.
Abstract
Transdermal drug delivery (TDD) involves drug administration across the skin which can prevent the drug from degradation in the gastrointestinal tract and first-pass effects of the liver associated with oral delivery. Utilization of the microneedles (MNs) can avoid the pain and inconvenience of intravenous injection. However, due to the thickness of viable epidermis, the height of the microneedles needs to be large enough (usually around 600 mm) to penetrate through the skin for effective TDD. To fabricate MNs with such height, various methods have been proposed and demonstrated, for example, ICP-RIE etching, photolithographic process and laser ablation. Meanwhile, compared to different types of MNs, dissolvable polymer MNs offer certain advantages such as added functionality, active and controlled release, improved resistance to shear-induced breakage, cost effectiveness, sufficient mechanical strength and additional safety. In this presentation, we will discuss two proposed techniques which could be attractive alternatives for fabrication of MNs. One is to construct the MNs (mold) via etching of polydimethyl siloxane (PDMS) micropillars and the other is to fabricate dissolvable polymer MNs via microfiltration. For the former, PDMS MNs with height around 650 mm can be obtained with different geometric shapes. For the latter, the flexible polymer MNs patch with the MNs height larger than 600 μm can be obtained within 1 hr.[:en]Speaker：Prof. Yi-Je Juang
Topic：Fabrication of flexible and dissolvable polymer microneedle patches via microfiltration
Date：10/16（五）15:30~17:20
Location：博雅館 201
Host ： Prof. Chih-Chen Hsieh
BIOGRAPHY
Dr. Juang received a B.S. degree in chemical engineering from National Taiwan University (Taipei, Taiwan) in 1993 and a Ph.D. degree in chemical engineering from The Ohio State University (Columbus, Ohio, USA) in 2001.
Currently, he is an associate professor of Department of Chemical Engineering at National Cheng Kung University in Taiwan. Before joining National Cheng Kung University in 2005, he worked as a process engineer at ACLARA BioSciences Company (California, USA), a product development manager at Bioprocessing Innovative Company (Ohio, USA) and a postdoctoral researcher at The Ohio State University (Ohio, USA). His research interest includes micro/nanofabrication, micro/nanofluidics, BioMEMS, and polymer microfabrication.
Dr. Juang is a member of “Society of Plastics Engineers-Taiwan Section” and “Nanotechnology and Micro System Association”.
Abstract
Transdermal drug delivery (TDD) involves drug administration across the skin which can prevent the drug from degradation in the gastrointestinal tract and first-pass effects of the liver associated with oral delivery. Utilization of the microneedles (MNs) can avoid the pain and inconvenience of intravenous injection. However, due to the thickness of viable epidermis, the height of the microneedles needs to be large enough (usually around 600 mm) to penetrate through the skin for effective TDD. To fabricate MNs with such height, various methods have been proposed and demonstrated, for example, ICP-RIE etching, photolithographic process and laser ablation. Meanwhile, compared to different types of MNs, dissolvable polymer MNs offer certain advantages such as added functionality, active and controlled release, improved resistance to shear-induced breakage, cost effectiveness, sufficient mechanical strength and additional safety. In this presentation, we will discuss two proposed techniques which could be attractive alternatives for fabrication of MNs. One is to construct the MNs (mold) via etching of polydimethyl siloxane (PDMS) micropillars and the other is to fabricate dissolvable polymer MNs via microfiltration. For the former, PDMS MNs with height around 650 mm can be obtained with different geometric shapes. For the latter, the flexible polymer MNs patch with the MNs height larger than 600 μm can be obtained within 1 hr.