講者：Prof. Julie Liu
演講題目：Engineering
Recombinant Protein-based Biomaterials for Stem Cell Differentiation and
Surgical Adhesive Applications
演講時間：5/6（三）下午2：00
演講地點：化工一教室
主持人：陳立仁教授
Engineering
Recombinant Protein-based Biomaterials for Stem Cell Differentiation and
Surgical Adhesive Applications
Julie Liu
School of Chemical Engineering, Purdue University
Abstract
We are designing genetically-engineered
protein biomaterials for tissue engineering and surgical adhesive applications.
To promote cell differentiation, we designed materials that contain 1) a
bioactive domain that interacts with cells, 2) resilin-based structural repeats
to confer the desired mechanical properties, and 3) crosslinking sites. Our
work demonstrates that the identity of the bioactive domain can influence or
promote adult mesenchymal stem cell differentiation to the osteogenic or
endothelial lineage.
For surgical adhesive applications, we
designed protein-based adhesives containing two domains: a structural domain
that provides flexibility and an adhesive domain that provides the ability to
adhere in wet environments. Initial results show high cytocompatibility
(>98% viability) and significant bulk adhesive strength (approximately 1
MPa). This new family of flexible adhesive proteins combines the mechanical
properties of elastin and the adhesive properties of mussel adhesive proteins.
Its unique properties are ideal for application as a soft tissue surgical
adhesive, as well as coatings for cell attachment or scaffolds for tissue
engineering.
Bio
Julie Liu received her B.S.E. in
chemical engineering from Princeton University. She was awarded a Whitaker
Graduate Fellowship and worked with David Tirrell at the California Institute
of Technology. Her doctoral research examined the cellular response to
protein-based matrices designed for small-diameter vascular grafts. After
obtaining her Ph.D. in chemical engineering, she received an NIH postdoctoral
fellowship to study skeletal biology with Jane Lian and Gary Stein in the
department of cell biology at the University of Massachusetts Medical School.
She is an associate professor of chemical engineering and biomedical engineering
at Purdue University. Her research interests include biomimetic materials,
tissue engineering, stem cell differentiation, surgical adhesives, and
detection of epigenetic modifications. Her research has been funded by the
National Science Foundation, National Institutes of Health, Department of
Defense, American Heart Association, and a 3M Nontenured Faculty Award.
關於本次演講資訊請參考附件檔案，謝謝。
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