講者：Prof. Colin Jamora
演講題目：Cellular and
molecular basis of cutaneous wound healing and diseases with a "wound
signature"
演講時間：3/7（五）15:30~17:20
演講地點：普通館 101
主持人：吳嘉文教授
Cellular and molecular basis of cutaneous wound
healing and diseases with a "wound signature"
Colin
Jamora
Associate
Professor
IFOM-inStem
Joint Research Laboratory, Institute for Stem
Email:
colinj@instem.res.in
The ultimate goal of the Jamora lab is to obtain a mechanistic
understanding of the cellular and molecular basis of tissue regeneration and
repair in order to control these processes in therapeutic applications. A wide array of experimental approaches
ranging from genetic engineering of mouse models to cell biology and
biochemistry to quantitative biology is brought to bear in these
investigations. This multidisciplinary approach is marshaled to gain a
fundamental understanding of tissue homeostasis, using the skin as an
experimental platform. Within the skin,
the epithelial compartment (the epidermis and hair follicle) is one of the few
structures in the mammalian body that undergoes cyclic regeneration throughout
the lifetime of the animal. Moreover, as
the primary mode of protection from physical and chemical assaults, the
epithelium is often damaged and has evolved an amazing capacity to rapidly
repair itself. Interestingly, multiple
epithelial stem cell niches in both the epidermis and hair follicle make
important contributions to the wound-healing program. Current efforts are aimed at unraveling the
interplay among the cells that mediate the three phases of the wound-healing
program: the inflammatory phase, proliferative phase, and remodeling
phase. Interestingly, many diseases
exploit and deregulate these processes, which has given rise to the resurgence
of the hypothesis of diseases with a “wound signature”. Consequently, though
the research projects are strongly rooted in basic biology, they also have
considerable potential to promote the development of novel therapeutics for a
variety of diseases.
關於本次演講資訊請參考附件檔案，謝謝。
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