講者：Prof. Annalisa Tirella
演講題目：How to play an active
role and interact with biological microsystems?
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演講時間：2/21(五)10：20AM
演講地點：化工館工223室
主持人：王勝仕教授
How to play
an active role and interact with biological microsystems?
Annalisa
Tirella
Institute
of Clinical Physiology, National Research Council, Pisa, Italy
New applications for hydrogels have emerged in
biotechnology and biomedical applications, but most notably in stem cell and
cancer research, cell therapy, tissue engineering, and in vitro models. These
applications require more than the typical triad of stimuli (i.e.
mechano-structural, physic-chemical and biochemical features) in a controlled
microenvironment. Indeed, in the context of investigating and then
recapitulating the complexity of biological systems, there is a need to
modulate and control microenvironments designed on biomimicry of the
extracellular matrix (ECM). Typically hydrogels have been tuned and used to
fabricate such microenvironments. Shaped as useful three-dimensional (3D)
systems, they were recently used as exploratory tools to study the presentation
of specific bioactive factors on cell fate. Using different methodologies
and/or fabrication tools, hydrogels micro-constructs can be assembled in
well-defined structural materials and surfaces that display sophisticated
functions in order to recreate a microenvironment with tailored properties. In
this perspective the nano-in-micro concept foresees the inclusion if nano-tools
(e.g. nanosensors, photo-sensitive biomolecules, drugs) in such gel systems.
Nano-in-micro spherical hydrogels can be easily designed and fabricated using different
rapid prototyping strategies. By entrapping several kinds of sensing, living
and active domains, nano-in-micro systems can be assembled to biomimic a target
physiological and living microenvironment. Thus, even being a Gulliver in a
system ruled by Lilliputians, this approach will enable the interrogation of biological
in vitro systems helping to understand the fate of many pathophysiological
states.
關於本次演講資訊請參考附件檔案，謝謝。
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