講者：Prof. Klavs F. Jensen
演講題目：Chemical and
Biological Microsystems – Advantages of going small
演講時間：1/13（一）下午4：00
演講地點：化工館化工一教室
主持人：王大銘教授
Klavs F. Jensen Bio:
Klavs F. Jensen is
Warren K. Lewis Professor and Head of the Chemical Department at the
Massachusetts Institute of Technology.
He received his chemical engineering education from the Technical
University of Denmark (M.Sc.) and University of Wisconsin-Madison (PhD). His research interests include microsystems for chemical and
biological discovery, synthesis and processing. Catalysis, chemical
kinetics and transport phenomena are also topics of interest along with
development of simulation approaches for reactive chemical and biological
systems. He is the co-author of more than 330 journal articles as well as
several edited volumes and 30 US patents.
He serves on advisory boards to universities, companies, professional
societies, and governments. He is the recipient of numerous awards, including
the Allan P. Colburn, Charles C.M. Stine, R.H. Wilhelm, and W.H. Walker Awards
of the American Institute of Chemical Engineers. Professor Jensen is a member
of the US National Academy of Engineering and the American Academy of Arts and
Science. He is also a Fellow of the American Association for the Advancement of
Science (AAAS), and the American Institute of Chemical Engineers, and the Royal
Society of Chemistry.
Abstract:
Microfabrication
techniques have fueled spectacular advances in the electronic and
telecommunications industries, and more recently, in microanalysis chips for
chemical and biological applications. These systems promise to transform
classical laboratory procedures into integrated systems capable of providing
new understanding of fundamental chemical and biological processes as well as
rapid, continuous discovery and development of new products with less use of resources
and waste generation. Chemical microsystems combine chemical-synthesis-on-a
chip and microscale separation to enable multiple synthesis steps, which are
further enhanced by information gained from integrating miniaturized sensors
and actuators. Biological studies are similarly accelerated by the integration
of cell manipulation and biochemical detection. Applications of chemical and
biological microsystems are illustrated with case studies drawn from chemical transformations,
synthesis and assembly of nano structures, and cellular manipulation. Emphasis
is placed on applications that are enabled by flow systems and are difficult to
perform by conventional techniques. Flow chemistry examples include the
creation of modular chemical plants for small scale pharmaceutical production. Cellular
manipulation is illustrated with microfluidic devices for delivery of
macromolecules and nanoparticles to the cytosol. This technique has superior
ability to deliver proteins, siRNA, and nanoparticles, while maintaining
material functionality and cell viability.
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