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趙 玲 教授 / Ling Chao Professor

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趙 玲 教授 / Ling Chao Professor

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仿生膜界面現象及工程實驗室 Biomembrane and Interfacial Engineering Lab 二館 生物界面現象 生物感測器仿細胞膜生物晶片 Biointerfacial phenomenaBiosensorsCell Membrane Mimic Bio-chips (02)3366-3023 BLDG.II (02)3366-9936 lingchao@ntu.edu.tw N411 趙玲 Ling Chao 化工二館(鄭江樓) CheE BLDG.II 教授 Professor N412

  • Introduction

    • Education Background
      • National Taiwan University, B.S. Ch.E., 2003
      • Massachusetts Institute of Technology, Ph.D. Ch.E., 2009
      • Cornell University, Post doc., 2009-2011

     

    • Research Topic
      • Cell Membrane Mimic Bio-chips
        Our research interest is to develop cell membrane mimic platforms to understand the underlying mechanisms of membrane related cellular processes for novel therapeutic applications. Cell membranes are the gateway for cells to send and receive signals and for pathogen infection. Membrane proteins are the primary drug targets; however, they are difficult to study, since their structures, functions, and activities are highly sensitive to their lipid membrane environments. Cell membrane mimic platforms allow these proteins to be studied in their native environments.
      • Phase Transformation and Transport Phenomena in Lipid Membranes
        The phase dynamics and species transport in lipid membranes has been suggested to influence many cellular processes. Incorporating microfluidic and microfabriaction techniques, we can have control over lipid membrane’s pre-determined constituents, the spatial organization of membranes and proteins, and when different biomolecules interact with each other. The spatio-temporal control, which is difficult to achieve in conventional methods, allows us to obtain fundamental understanding of biomembrane related cellular processes and to discover new biophysical phenomena.

     

    • Recent Research Topic
      Current research programs include:
      • Studying phase transformation phenomena in bio-membranes
      • Exploring physical pathway for potential therapeutic applications of phospholipase related disease
      • Liposome based drug delivery application
      • Bio-interface engineering for studying peripheral protein-lipid membrane interactions
        Use microfluidic and microfabrication techniques to develop composite membranes to study how the membrane catalyzes membrane protein structure changes
        High throughput screening of environmental conditions in microfluidic devices

  • Honor

    1. 2022年獲李長榮學術研究傑出青年教授獎
    2. 2020年獲得科技部哥倫布計畫
    3. 獲得第十一屆台灣女科學家新秀獎(2018)
    4. 擔任scientific reports 之編委會委員(editorial board member)
    5. 國立台灣大學教學優良獎(2018)
    6. 獲得傑出人才基金會頒發的年輕學者創新獎(2017)
    7. 獲得日本化學學會頒發的 “Lectureship Award 2017”
    8. 獲得科技部2016優秀年輕學者計畫
    9. 台灣化工學會2015年優秀年輕學者
    10. 台灣化工學會2015年化工傑作獎
    11. Lab on a chip 期刊封面+2014 熱門文章
    12. 指導專題生詹雅筑同學獲得科技部106年度大專學生研究計畫研究創作獎
    13. Advised graduate student Yi-Kuan Meng on winning First Place Award in poster presentation, the 69th Taiwan ChE annual meeting, Dec. 02-03, Tamsui, Taiwan, 2022.
    14. Advised graduate student Tse-Tzu Liu on winning Honorable Mention Award in English oral presentation, the 69th Taiwan ChE annual meeting, Dec. 02-03, Tamsui, Taiwan, 2022.
    15. Advised graduate student Che-Lun Chin on winning First Place Award in poster presentation, the 69th Taiwan ChE annual meeting, Dec. 02-03, Tamsui, Taiwan, 2022.
    16. Advised graduate student Che-Lun Chin on winning First Place Award in poster presentation, Taiwan ChE annual meeting, Jan. 06-07, Kaohsiung, Taiwan, 2022.
    17. Advised graduate student Hao-Chin Yang on winning First Place Award in poster presentation in Transport Phenomenon Group, Taiwan ChE annual meeting, Jan. 06-07, Kaohsiung, Taiwan, 2022
    18. Advised graduate student Sin-Han Huang on winning Second Place Award in poster presentation in Transport Phenomenon Group, Taiwan ChE annual meeting, Jan. 06-07, Kaohsiung, Taiwan, 2022
    19. Advised undergraduate student Meng-Hua Yang on winning the Gold Medal Award 2020 in the Undergraduate Research Competition in the Dept. of Chemical Engineering at National Taiwan University
    20. Advised undergraduate student Chin-Lun Chin on winning the Bronze Medal Award 2020 in the Undergraduate Research Competition in the Dept. of Chemical Engineering at National Taiwan University
    21. Advised undergraduate student Jia-Wei Kuo on winning the Best Undergraduate Thesis Award 2019 in National Taiwan University (only one in the College of Engineering)
    22. Advised undergraduate students, Zhe-Han Kuo, Jia-Wei Kuo, on winning the Gold Medal Award 2019 in the Undergraduate Research Competition in the Dept. of Chemical Engineering at National Taiwan University
    23. Advised undergraduate student Chin-Chun Huang on winning the Silver Medal Award 2018 in the Undergraduate Research Competition in the Dept. of Chemical Engineering at National Taiwan University
    24. Advised undergraduate student Kuan-Lin Chen on winning the Bronze Medal Award 2018 in the Undergraduate Research Competition in the Dept. of Chemical Engineering at National Taiwan University
    25. Advised undergraduate student Ya-Chu Chan on winning the 2017 Undergraduate Research Novelty Award from the Ministry of Science and Technology in Taiwan
    26. Advised graduate student Yu-Ting Lin on winning First Place Award in oral presentation in Thermodynamic and Interface Engineering Group, Taiwan ChE annual meeting, Nov. 26, Taoyuan, Taiwan, 2016. The presentation title is “Development of a surface plasmon resonance and plasmon-waveguide resonance combined chip for studying the transport behaviors of cell membrane transport proteins”
    27. Advised graduate student Shao-Wei Lyu on winning First Place Award in poster presentation in Bioengineering Group, Taiwan ChE annual meeting, Nov. 26, Taoyuan, Taiwan, 2016. The presentation title is “Using Cell Membrane Blebs Induced by Hypertonic Buffer to Form Supported Membrane Platforms with Native Membrane Proteins”.
    28. Advised graduate student Kai-Hung Hsiao on winning First Place Award in poster presentation in Transport Phenomenon Group, Taiwan ChE annual meeting, Nov. 26, Taoyuan, Taiwan, 2016. The presentation title is “Using Magnetic Field to Purify Membrane Proteins in Supported Cell Plasma Membranes”.
    29. Advised graduate student U-Ting Chiu on winning Second Place Award in poster presentation in Energy Group, Taiwan ChE annual meeting, Nov. 26, Taoyuan, Taiwan, 2016. The presentation title is “Using a Light-Driven Proton Pump Protein to Develop Devices for Photocurrent Generation”.
    30. Advised graduate student Chia-Yee Hong on winning the Best Poster Award in Taiwan Interfacial Science Annual Meeting, June. 24, Taipei, Taiwan, 2016. The presentation title is “Nonspecific Binding Domains in Lipid Membranes Induced by Phospholipase A2”.
    31. Advised graduate student Jou-Fang Wang on winning the Excellent Poster Award in Taiwan Interfacial Science Annual Meeting, June. 24, Taipei, Taiwan, 2016. The presentation title is “Developing Platforms to Study Transmembrane Proteins from either Intracellular Side or Extracellular Side”.
    32. Advised graduate student Shu-Kai Hu on winning the Presentation Award in Graduate Student English Oral Report in the 62th TWICHE Annual Meeting, Nov. 6-7, Kaohsiung, Taiwan, 2015. The presentation title is “Studying Hydrodynamic and Induced Drag Forces on Cell Membrane Embedded Species in Supported Lipid Bilayers”.
    33. Advised graduate student Shu-Kai Hu on winning the Presentation Award in Graduate Student English Oral Presentation in the BEST Conference & International Symposium on Biotechnology and Bioengineering, Jun. 26-27, Taipei, Taiwan, 2015. The presentation title is “Using Spatially Arranged Lipid Membranes to Reveal Hydrodynamic Separation Mechanism of Biomolecules Embedded in Lipid Membranes”.
    34. Advised graduate student Cheng-Jung Guo on winning First Place Award in poster presentation in Thermodynamic and Interface Engineering Group in the 61th TWICHE Annual Meeting, Dec. 12-13, Taoyuan, Taiwan, 2014. The poster title is “Using Surface Plasmon Resonance to Study Species Transport across Lipid Membranes.”
    35. Advised graduate student Yu-Ming Tu on winning the Best Presentation Award in Graduate Student English Oral Report in the 61th TWICHE Annual Meeting, Dec. 12-13, Taoyuan, Taiwan, 2014. The presentation is "Study of Min Protein- Induced Membrane Waves in vitro.
    36. Advised graduate student Po-Chieh Chiang on winning the Best Poster Award in poster presentation in Biochemical and Biomedical Engineering Group in the 61th TWICHE Annual Meeting, Dec. 12-13, Taoyuan, Taiwan, 2014. The poster title is "Using Giant Plasma Membrane Vesicles from Cells to form Supported Lipid Bilayers."
    37. Advised graduate student Yu-Ming Tu on winning the Best Oral Presentation Award in the 3rd International Symposium of Materials on Regenerative Medicine (ISOMRM), Aug. 27-29, Tao-Yuan, Taiwan. The presentation is "Mechanism Study of Min Protein-Induced Membrane Waves in vitro.
    38. Advised graduate student Yu-Ming Tu on winning the Best Oral Presentation Award in International Symposium on Chemical Environmental Biomedical Technology (isCEBT) Sep.10-14, 2014, Chang Gung University, Tao-Yuan, Taiwan, 2014. The presentation is "Study of Min Protein-Induced Membrane Waves in vitro."
    39. Advised graduate student Chung-Ta Han on winning the Best Presentation Award in Graduate Student English Oral Report in the 60th TWICHE Annual Meeting, Nov. 22-23, Taipei, Taiwan, 2013. The presentation is “Using Phospholipase A2 to Create Air-stable Supported Lipid Bilayers.”
    40. Advised graduate student Shu-Kai Hu on winning the Best Poster Award in Transportation Phenomena and Separation Technology Group in the 60th TWICHE Annual Meeting, Nov. 22-23, Taipei, Taiwan, 2013. The poster title is "Using Crosslinkable Diacetylene Phospholipids to Construct Two-Dimensional Packed Beds in Supported Lipid Bilayer Separation Platforms."
    41. Advised graduate student Charng-yu Lin on winning the First Place Award in poster presentation and First Place Award in English oral presentation in The 18th Biophysics Conference, Jun 27-29, Taipei, Taiwan, 2013. The poster and presentation titles are “Tunable Nucleation Time of Functional Enzyme-Lipid Complex Studied by Membrane Array Statistic Tool.”
    42. Advised graduate student Charng-yu Lin on winning the Best Poster Award in poster presentation in Transportation Phenomena and Separation Technology Group in the 59th TWICHE Annual Meeting, Nov. 23-24, Taichung, Taiwan, 2012. The poster title is "Tunable Nucleation Time of Functional Sphingomyelinase-lipid Complex Studied by Membrane Array Statistic Tool."

  • Publications

    1. Chia-Wei Kuo, Tse-Han Kuo, Hui-An Lee, Yu-Ting Lin, Cheng-Jung Kuo, Kai-Hung Hsiao, Meng-Hua Yang, Kevin Tanady, Shu-Yu Chang, Tzy-Rong Lin, and Ling Chao*, Label-free detection of transport kinetics and inhibitor binding of membrane transport proteins with a two-mode plasmonic sensor, Biosensors and Bioelectronics: X, 2022, Volume 11, 100183
    2. Sin-Han Huang, Bo-Chuan Huang, and Ling Chao*, Development of Cell Membrane Electrophoresis to Measure the Diffusivity of a Native Transmembrane Protein, Analytical Chemistry, 2022, 94, 10, 4531–4537 (SCI, Chemistry, Analytical, 8/87, IF: 7.0)
    3. Yu-Shan Chang, Hao-Cin Yang, and Ling Chao*, Formation of Supported Thylakoid Membrane Bioanodes for Effective Electron Transfer and Stable Photocurrent, ACS Applied Materials & Interfaces, 2022, 14, 19, 22216–22224 (SCI, Multidisciplinary, 44/334, IF=9.2)
    4. U-Ting Chiu, and Ling Chao*, “Electron transfer through protein-bound water and its bioelectronic application”, Biosensors and Bioelectronics, 2019, 136, 16-22 (SCI, IF: 9.5)
    5. Shu-Kai Hu, Fang-Yen Lo, Chih-Chen Hsieh, and Ling Chao*, “Sensing Ability and Formation Criterion of Fluid Supported Lipid Bilayer Coated Graphene Field-Effect Transistors”, ACS Sensors, 2019, 4 (4), 892–899 (SCI, IF: 6.9) (featured on the cover page of Volume 4, Issue 4, 2019)
    6. U-Ting Chiu, Bo-Fan Lee, Shu-Kai Hu, Ting-Feng Yu, Wen-Ya Lee*, and Ling Chao*, “Graphene Memory Based on a Tunable Nanometer-Thin Water Layer”, J. Phys. Chem. C, 2019, 12317, 10842-10848 (SCI, IF: 4.5) (featured on the cover page of Volume 123, Issue 17, 2019)
    7. Shao-Wei Lyu, Jou-Fang Wang, and Ling Chao*, “Constructing Supported Cell Membranes with Controllable Orientation”, 2019, Scientific Reports volume 9: 2747, p1-p8 (SCI, IF: 4.5)
    8. Yu-Ling Shih*, Ling-Ting Huang, Yu-Ming Tu, Bo-Fan Lee, Yu-Chiuan Bau, Chia Yee Hong, Hsiao-lin Lee, Yan-Ping Shih, Min-Feng Hsu, Zheng-Xin Lu, Jui-Szu Chen, and Ling Chao*, “Active Transport of Membrane Components by Self-Organization of the Min Proteins”, Biophysical Journal, 2019, 116, 1469–1482 (SCI, IF: 3.8) (featured on the cover page of Volume 116, Issue 8, 2019)
    9. Po-Chieh Chiang, Kevin Tanady, Ling-Ting Huang, and Ling Chao*, “Rupturing Giant Plasma Membrane Vesicles to Form Micron-sized Supported Cell Plasma Membranes with Native Transmembrane Proteins”, Scientific Reports, 2017, 7: 15139
    10. B Lin, S Tsao, Alex Chen, Shu-Kai Hu, Ling Chao, and PG Chao*, “Lipid rafts sense and direct electric field-induced migration”, Proceedings of the National Academy of Sciences(PNAS), 2017, 114 (32), 8568-8573
    11. Hsing-Ying Tung, Ting-Pi Sun, Ho-Yi Sun, Zhen-Yu Guan. Shu-Kai Hu, Ling Chao, and Hsien-Yeh Chen*, “Construction and control of 3D porous structure based on vapor deposition on sublimation solids”, Applied Materialstoday, 2017, Volume 7, 77-81

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    Last Updated

    2025-04-16
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